Scientists create mice with two biological fathers

10 March 2023

Prof. Katsuhiko Hayashi, a globally respected expert in the field, has created eggs from the cells of male mice. Details were presented at the human gene-editing summit at the Crick Institute in London. (Credit: YouTube / screengrab)

The Guardian reports:

Scientists have created mice with two biological fathers by generating eggs from male cells, a development that opens up radical new possibilities for reproduction.

The advance could ultimately pave the way for treatments for severe forms of infertility, as well as raising the tantalising prospect of same-sex couples being able to have a biological child together in the future.

“This is the first case of making robust mammal oocytes from male cells,” said Katsuhiko Hayashi, who led the work at Kyushu University in Japan and is internationally renowned as a pioneer in the field of lab-grown eggs and sperm.

Prof. Hayashi presented the development at the Third International Summit on Human Genome Editing at the Francis Crick Institute in London on 8 March. He predicts that it will be technically possible to create a viable human egg from a male skin cell within a decade.

The BBC reports:

Prof George Daley of Harvard Medical School, who is not involved in the research, said that there was still a long way to go before society was faced with such a decision.

“Hayashi’s work is unpublished but fascinating. [Doing this on Humans] is harder than the mouse,” he said. “We still don’t understand enough of the unique biology of human gametogenesis (the formation of reproductive cells) to reproduce Hayashi’s provocative work in mice”.

Prof Hayashi, a globally respected expert in the field, told delegates at the meeting that the work was at a very early stage. The eggs, he said were of low quality and the technique could not be used safely on humans at this stage.

The Century of Kyushu U: Prof. Katsuhiko Hayashi

Lab Creates Mice From Two Fathers in scientific breakthrough

Newly developed eggs from male cells enable scientists to produce mice with two fathers

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